While the opiate receptor relies on G protein coupling for signal transduction, this receptor was found to utilize arrestin activation for internalization with the receptor. Or else, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable advancement in binding efficacy. This binding even… Read More

Researchers have not long ago determined and succeeded in synthesizing conolidine, a purely natural compound that reveals promise for a potent analgesic agent with a far more favorable safety profile. Although the exact mechanism of motion remains elusive, it can be at present postulated that conolidine might have several biologic targets. Presentl… Read More

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